Publications

  1. “Discovery of a novel, potent and orally active series of g -lactams as selective NK1 antagonists.”  Paliwal, S.; Reichard, G. A.; Shah, S.; Wrobleski, M. L.; Wang, C.; Stengone, C.; Tsui, H.-C.; Xiao, D.; Duffy, R. A.; Lachowicz, J. E.; Nomeir, A. A.; Varty, G. B.; Shih, N.-Y.  Bioorg. Med. Chem. Lett.  2008, 18(14), 4168.
  2. “SARVision Plus by ChemApps” Reichard, G. A. J. Chem. Inf. Model.  2008,  48(6), 1287.
  3. “Practical asymmetric synthesis of potent NK1 antagonists” Tsui, H.-C; Paliwal, S.; Reichard, G. A..; Xiao, D.; Wang, C.; Wrobleski, M. L.; Shah, S.; Duffy, R. A.; Lachowicz, J.; Morgan, C.; Nomeir, A.; Varty, G.; Shih, N.-Y.Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23 (2007),MEDI-421.
  4. “Novel g-lactams as potent, selective and orally active NK1 antagonists” Paliwal, S.; Reichard, G. A.; Shah, S.; Wrobleski, M. L.; Wang, C.; Stengone, C.; Tsui, H.-C.; Xiao, D.; Duffy, R. A.; Lachowicz, J. E.; Liu, F.; Nomeir, A. A.; Varty, G. B.; Shih, N.-Y. Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23 (2007),  MEDI-422.
  5. “Two complementary, diversity-driven asymmetric syntheses of a 2,2-disubstituted piperidine NK1 antagonist”    Xiao, D.; Wang, C.; Palani, A.; Reichard, G. A.; Aslanian, R.; Shih, N.-Y.; Buevich, A.   Tetrahedron: Asymmetry 2006, 17, 2596.
  6. “Improving metabolism of novel cyclic urea NK1 antagonists with amine capping groups” Xiao, D.; Stengone, C.; Reichard, G. A.; Shih, N.-Y.; Duffy, R. A.; Randolph, G.; Lachowicz, J.; Varty, G.; Morgan, C.; Liu, F.; Nomeir, A.   Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14 (2006), MEDI-477. 
  7. “Series of potent, orally active alpha,alpha-disubstituted piperidine NK1 antagonists”  Xiao, D.; Wang, C.; Reichard, G. A.; Tsui, H.-C.; Paliwal, S.; Palani, A.; Shih, N.-Y.; Duffy, R. A.; Randolph, G.; Lachowicz, J.; Varty, G.; Morgan, C.; Liu, F.; Nomeir, A.  Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14 (2006),  MEDI-476. 
  8. “An efficient approach for the rapid assessment of oral rat exposures for new chemical entities in drug discovery”  Han, H.-K.; Sadagopan, N.; Reichard, G.A.; Yapa, U.; Zhu, T.; Hubbel, A.; Johnson, K.; Brodfuehrer, J.  Journal of Pharmaceutical Sciences 2006, 95, 1684.
  9. “Cyclobutane derivatives as potent NK1 selective antagonists” Wrobleski, M. L.; Reichard, G. A.; Paliwal, S.; Shah, S.; Tsui, H.-C.; Duffy, R. A.; Lachowicz, J. E.; Morgan, C. A.; Varty, G. B.; Shih, N.-Y.  Bioorg. Med. Chem. Lett. 2006, 16, 3859. 
  10. “Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions” Shue, H. J.; Chen, X.; Schwerdt, J. H.; Paliwal, S.; Blythin, D. J.; Lin, L.; Gu, D.; Wang, C.; Reichard, G. A.; Wang, H.; Piwinski, J. J.; Duffy, R. A.; Lachowicz, J. E.; Coffin, V. L.; Nomeir, A. A.; Morgan, C. A.; Varty, G. B.; Shih, N.-Y.  Bioorg. Med. Chem. Lett.  2006, 16, 1065. 
  11. “Cyclic urea derivatives as potent NK1 selective antagonists” Shue, H. J.; Chen, X; Shih, N.-Y; Blythin, D. J.; Paliwal, S.; Lin, L.; Gu, D.; Schwerdt, J. H.; Shah, S; Reichard,G. A.; Piwinski, John J.; Duffy, R. A.; Lachowicz, J. E.; Coffin, V. L.; Liu, F.; Nomeir, A. A.; Morgan, C. A.; Varty, G. B.  . Bioorg. Med. Chem. Lett.  2005, 15, 3896. 
  12. “The Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazolidinones: Potent NK1 Antagonists” Reichard, G. A.; Stengone, C. A.; Paliwal, S.; Mergelsberg, I.; Majmundar, S.; Wang, C.; Tiberi, R.; McPhail, A. T.; Piwinski, J. J.; Shih, N.-Y. Org. Lett. 2003, 5, 4249.
  13. “Development and Potential Utility of Dual and Triple NK Receptor Antagonists” Rizzo, C. A.; Anthes, J. C.; Corboz, M. R.; Chapman, R. W.; Shih, N.-Y.; Reichard, G. A.; Ng, Kwokei J.; Hey, J. A. Current Topics in Medicinal Chemistry. 2003, 3, 1410.
  14. “Isolation of Circulating Metabolites in Drug Discovery Using High-Performance Liquid Chromatography, and their Identification by Liquid Chromatography Coupled with Tandem Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy” Kim, H.; Feng, W.; Chan, T.-M.; Rindgen, D.; Bryant, M.; Cox, K. A.; Xia, Y.; Reichard, G.; Paliwal, S.; Hesk, D.; Palamanda, J.; White, R. E.; Nomeir, A. A.   Journal of Separation Science. 2002, 25, 877.
  15. “SCH 206272: A Potent, Orally Active Tachykinin NK1, NK2, and NK3 Receptor Antagonist” Anthes, J. C.; Chapman, .R. W.; Richard, C.; Eckel, S.; Corboz, M.; Hey, J. A.; Fernandez, X.; Greenfeder, S.; McLeod, R.; Sehring, S.; Rizzo, C.; Crawley, Y.; Shih, N.-Y.; Piwinski, J.; Reichard, G.; Ting, P.; Carruthers, N.; Cuss, F. M.; Billah, M.; Kreutner, W.; Egan, R. W.  European Journal of Pharmacology 2002, 450, 191. 
  16. “Preparation of Oxime Dual NK1/NK2 Antagonists with Reduced NK3 Affinity” Reichard, G. A.; Grice, C. A.; Shih, N.-Y.; Spitler, J.; Majmundar, S.; Wang, S. D.; Paliwal, S.; Anthes, J. C.; Piwinski, J. J. Bioorg. Med. Chem. Lett. 2002, 12, 2355.
  17. “The Asymmetric Synthesis of (3R)-N-Methyl-2-oxo-[1,4'-bipiperidine]-3-acetamide in Quantity” Reichard, G. A.; Spitler, J.; Mergelsberg, I.; Miller, A.; Wong, G.; Raghavan, R.;  Jenkins, J.; Gan, T.; McPhail, A. T. Tetrahedron: Asymmetry 2002, 13, 939.
  18. “Structure Activity Relationships of Oxime Neurokinin Antagonists: Oxime Modifications”  Reichard, G. A.; Spitler, J.; Aslanian, R.; Mutahi, M.; Shih, N.-Y.; Lin, L.; Ting, P. C.; Anthes, J. C.; Piwinski, J. J.  Bioorg. Med. Chem. Lett. 2002, 12, 833.
  19. “Synthesis and Structure-Activity Relationships of Oxime Neurokinin Antagonists: Discovery of Potent Arylamides.”  Shih, N.-Y.; Albanese, M.; Anthes, J. C.; Carruthers, N. I.; Grice, C.A.; Lin, L.; Mangiaracina, P.; Reichard, G. A.; Schwerdt, J.; Seidl, V.; Wong, S.-C.; Piwinski, J. J. Bioorg. Med. Chem. Lett. 2002, 12, 141.
  20. “The Design and Synthesis of Novel NK1/NK2 Dual Antagonists” Reichard, G. A.;  Ball, Z. T.; Aslanian, R.; Anthes, J. C.; Shih, N.-Y.; Piwinski,  J. J. Bioorg. Med. Chem. Lett.  2000, 10, 2329.
  21. “Design and Synthesis of the Novel and Orally Active Dual NK1/NK2 Antagonist, Sch 205528” Shih, N.-Y.; Albanese, M.; Aslanian, R.; Blythin, D.; Chen, X.; Duguma, L.; Gu, D.; Friary, R.; Lee, J.; Lin, L.; Mangiaracina, P.; McCormick, K.; Mohrbutter, R.; Mutahi, M.; Piwinski, J.; Reichard, G.; Schwerdt, J.; Shue, H.-J.; Spitler, J.; Ting, P.; Wong, J.; Wong, S.-C.; Carruthers, N.; Grice, C.; Lupo, A. Jr.; Anthes, J.; Chapman, R.; Hey, J.; Kreutner, W.; Rizzo, C. Book of Abstracts, 220th ACS National Meeting, Washington, DC, August 20-24 (2000),  MEDI-129. 
  22. “Synthetic and Biological Studies with Lactacystin and Analogs” Corey, E. J.; Reichard, G. A.; Li, W. -D. Z.; Choi, S.; Nagamitsu, T.; Fenteany, G.; Schreiber, S. L.  Book of Abstracts, 216th ACS National Meeting, Boston, August 23-27  (1998),  ORGN-500. 
  23. "A New Magnesium-Catalyzed Doubly Diastereoselective anti-Aldol Reaction Leads to a Highly Efficient Process for the Total Synthesis of Lactacystin in Quantity"  Corey, E. J.; Li, W.; Reichard, G. A. J. Am. Chem. Soc. 1998, 120, 2330.
  24. “Total Synthesis of Lactacystin. An Enantioselective Synthesis of (5R)-Lactacystin. Total Synthesis of (+)-Lactacystin, the First Non-Protein Neurotrophic Factor. Total Synthesis of (+)-Lactacystin from (R)-Glutamate” Corey, E. J.; Reichard, G. A.; Corey, E. J.; Choi, S.; Sunazuka, T.; Nagamitsu, T.; Matsuzaki, K.; Tanaka, H.; Omura, S.; et al.  Chemtracts:  Org. Chem. 1994, 7(4), 266.
  25. "A b-Lactone Related to Lactacystin Induces Neurite Outgrowth in a Neuroblastoma Cell Line and Inhibits Cell Cycle Progression in an Osteosarcoma Cell Line" Fenteany, G., Standaert, R. F., Reichard, G. A., Corey, E. J., Schreiber, S. L. Proc. Natl. Acad. Sci. USA., 1994, 91, 3358.
  26. "Synthesis and X-Ray Structure of a Potent Superpositional Analog of the Enantiomeric Forms of Fluoxetine" Corey, E. J.; Reichard, G. A., Sarshar, S.  Bioorg. Med. Chem. Lett. 1993, 3, 2635.
  27. "Studies on the Total Synthesis of Lactacystin. An Improved Aldol Coupling Reaction and a b-Lactone Intermediate in Thiol Ester Formation" Corey, E. J.; Reichard, G. A., Kania, R.  Tetrahedron Lett. 1993, 34, 6977.
  28. "Synthesis of (6R, 7S)-Lactacystin and 6-Deoxylactacystin from a Common Intermediate" Corey, E. J.; Reichard, G. A. Tetrahedron Lett. 1993, 34, 6973.
  29. "Total Synthesis of Lactacystin" Corey, E. J.; Reichard, G. A. J. Am. Chem. Soc. 1992, 114, 10677.
  30. "(+)-1(S), 5(R), 8(S)-8-Phenyl-2-azabicyclo[3.3.0]octan-8-ol N,O-methylboronate and its Enantiomer, Chiral Chemzymes which Serve as Catalysts for their Own Synthesis" Corey, E. J.; Chen, C.-P.; Reichard, G.A. Tetrahedron Lett. 1989, 30, 5547.
  31. "Enantioselective and Practical Syntheses of R- and S-Fluoxetines" Corey, E. J.; Reichard, G. A. Tetrahedron Lett. 1989, 30, 5207.